Flibanserin

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Flibanserin Approval: Facts or Feelings?

On August 18, 2015, the U.S. Food and Drug Administration (FDA) approved a first in class multifunctional serotonin agonist and antagonist medication, flibanserin, for the treatment of generalized acquired hypoactive sexual desire disorder (HSDD) in premenopausal women. This approval was surrounded by political posturing that has resulted in naysayers attacking the science based on their feelin...

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Female sexual dysfunction: a focus on flibanserin

Flibanserin is the first US Food and Drug Administration (FDA)-approved option for sexual dysfunction, specifically low sexual desire. Until recently, there were no FDA-approved medication options to assist the ~40% of women affected by female sexual dysfunction (FSD). Often, patients report feeling uncomfortable discussing sexual health, identifying a strong need for health care professionals ...

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Flibanserin for Treating Hypoactive Sexual Desire Disorder

There have been several products developed for male sexual dysfunction. However, developing agents for female sexual dysfunction is lagging behind for various reasons. Sildenafil citrate (Viagra) and Tadalafil (Cialis), which have been prescribed for male sexual function disorders, are known to act on vessels.[1] On the other hand, flibanserin is thought to act on brain. Flibanserin has been ap...

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Margaret McCartney: Flibanserin for low sexual desire is not feminism.

TheUKMedicines and Healthcare Products Regulatory Agency will neither confirm nor deny it, but flibanserin is likely to be coming to British shores. Its maker, Sprout Pharmaceuticals, told me that it is “committed to working closely with other regulatory bodies outside the US . . . to bring to market a safe and effective treatment for the millions of women around the world affected by distressi...

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Region-dependent effects of flibanserin and buspirone on adenylyl cyclase activity in the human brain.

The mode of action of antidepressant drugs may be related to mechanisms of receptor adaptation, involving overall the serotonin 1A (5-HT1A) receptor subtype. However, so far, the clinical effectiveness of selective compounds acting at this level has proved disappointing. This could be explained by the heterogeneity of 5-HT1A receptors within the central nervous system. In animals, two 5-HT1A ag...

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ژورنال

عنوان ژورنال: Archives of Sexual Behavior

سال: 2015

ISSN: 0004-0002,1573-2800

DOI: 10.1007/s10508-015-0617-y